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Tanner Notes Improved COVID-19 Outcomes With Blood Plasma, Encourages Donations From Recovered Patients



Tanner is encouraging recovered COVID-19 patients to donate their antibody-rich blood plasma after promising results from the system’s participation in a Mayo Clinic trial that infused critically ill patients with the plasma.

Blood plasma has been employed successfully in previous pandemics and provides an opportunity for patients who recover from COVID-19 — and often feel very fortunate — to help others stricken with the disease.

If you have fully recovered from the virus, you may also donate.

Tanner Health System is one of almost 2,200 healthcare systems across the country that joined the Mayo Clinic Expanded Access Program to test the efficacy of convalescent plasma — plasma from someone who has overcome COVID-19 — to help other sick patients survive the disease or recover faster.

“Liquid gold” can save lives. Blood plasma is sometimes referred to as “liquid gold” due to its potentially lifesaving contents and the rich color of the plasma once it’s separated from red blood cells during the donation process.Blood plasma image

Convalescent plasma is considered an experimental treatment to treat this new infection, according to Bonnie Boles, MD, the vice president of clinical transformation who — along with Laura Larson, MD, a board-certified infectious disease specialist and medical director of infection prevention — is overseeing the convalescent plasma transfusion project for Tanner.

“We have no vaccine or clear-cut treatment for COVID-19 yet, and people are still getting sick,” said Dr. Boles. “Everyone wants to know what they can do to help, and convalescent plasma is potentially life-saving. Its track record with other viruses is well-established, including Ebola in 2019, H1N1 influenza in 2009, avian flu in 2003, SARS in 2002 and even the Spanish Flu back in 1918.

“It’s very encouraging for patients and their families that it could help sick patients improve or prevent them from getting sicker," she said, "and, if it is proven effective, we will be better prepared for a possible second wave of COVID-19 this fall before a vaccine can be developed and approved for wide-scale use.”

Identifying eligible plasma donors

The American Red Cross is coordinating the donor identification process, including testing to confirm the presence of antibodies. Tanner has reached out to some of its COVID-19 patients by phone to make them aware of the opportunity to donate.

The requirements for donors include:

  • At least 17 years old and weigh 110 pounds. Additional weight requirements apply for donors 18 or younger;
  • In good health. You generally feel well, even if you're being treated for a chronic condition; and
  • Have a prior, verified diagnosis of COVID-19, but are now symptom-free and fully recovered from COVID-19.

    Patients meeting all the criteria above and willing to help should Complete the “Donor Request” form by visiting the Red Cross website at www.redcrossblood.org and clicking “Submit.” If you do not have access to a computer or smartphone, call the Red Cross at 1-800-733-2767.

    Donating convalescent plasma is like donating blood – but donors get their red blood cells back!

    Once approved, the donation of blood plasma is similar to donating whole blood and takes about the same amount of time – roughly an hour. The antibody-rich plasma is separated from the red blood cells, which are returned to the donor’s body. The donor’s body quickly replaces the extracted plasma; another donation is possible in about a week to 10 days. For typical whole-blood donations, a three-month waiting period is required in between donations.

    According to Dr. Boles, the typical donation is 700 milliliters of plasma. The typical infusion for a sick patient is 200 milliliters, so a single typical donation can be used to help up to three patients. 

Receiving convalescent plasma

With the Mayo Clinic trial guidelines and still-developing pipeline for plasma donations, only the sickest patients are currently eligible to receive plasma donations.

According to Dr. Boles, patients eligible to receive the plasma must be critically ill with respiratory failure, on a ventilator or likely to go on a ventilatory, and likely to develop other organ failure.  Blood type must also be matched, as with whole blood transfusions. Due to the critical state of eligible patients, there is a race against time to get the donations to patients.

Dr. Boles encourages those who have recovered from COVID-19 to consider donating their plasma to this nationwide study.

“You can not only support our community’s participation in this study to determine convalescent plasma’s effectiveness, but you may save lives and answer questions about this potential treatment for many,” she said.

More about Tanner’s COVID-19 response can be found at tanner.org/ncov.
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